The Proteas will play their first match since the 2019 World Cup when they face India in the first of three T20Is in Dharamshala on Sunday.
With a new coach - or interim team director, if you prefer - in Enoch Nkwe, a new-look backroom team, a new structure and a new skipper in Quinton de Kock, it is the dawn of a new era for South African cricket.
The disappointments of the World Cup under Ottis Gibson and Faf du Plessis, where the Proteas finished 7th, are now firmly in the past.
The task over the next few weeks is for this side to get back on its feet as soon as possible and earn back the faith of a South African cricketing public that is far from convinced things will get better anytime soon.
The Proteas will play three T20Is and then three Test matches in India in what is the most daunting of opening assignments for Nkwe.
Du Plessis is not in the squad for the T20s, but he is set to return and lead in the Test series while he remains part of the long-term T20 plans with next year's World Cup in Australia in mind.
The 14-man squad for the T20Is does include a number of familiar, experienced faces, but there is certainly the feeling of starting fresh with the likes of Du Plessis, Hashim Amla, JP Duminy and Imran Tahir all missing.